| Rank | Difference | Date | Opponent | | Score | Location | Click for details |
| 1 | 53 | Fri, Nov 5, 2004 | Our Lady of Mercy | W | 53-0 | H | ['more'] |
| The Our Lady of Mercy Bobcats won their first game of the year in the last week of the regular season to earn a #4 playoff seed. Unfortunately that earned them a visit to Lincolnton. The Bobcats tried to slow down the game, but it didn't help much. It was 39-0 at the half, with the second half played under mercy rules. |
| 2 | 49 | Fri, Dec 5, 2003 | Metter | W | 56-7 | T | ['more'] |
| LC totalled 548 yards offense, scored 4 3rd qtr points in this rout. Metter 11-1, #4 in polls, QB Zach Stanford had passed for over 2800 yrds and 27 TDs, but Devils stopped him with 13/34/155/1 and 1 22yd TD. One of best LC games ever played. |
| 3 | 48 | Fri, Nov 15, 1991 | Portal | W | 48-0 | H | ['more'] |
| (Wilk14, Lo13 in other 4-A game) Sapp 32/128 |
| 4 | 45 | Fri, Nov 17, 2006 | Trion | W | 53-8 | H | ['more'] |
| Campbell's 399th overall win and 99th playoff win. Trion zero net yards at half, LC leading 41-0. Second half played under mercy rules. Trion scored late against Devil JV. |
| 5 | 43 | Fri, Nov 12, 2010 | Pace Academy | W | 49-6 | H | ['more'] |
| Pace Academy, the #3 seed from 5-A, was 9-1 in its third year of football. This was the Knights' first playoff game, first game against a public school, and second game outside of Atlanta.
The Red Devils jumped out to a 14-0 lead before Pace's precision passing game closed the gap to 14-6 midway the second. Ercell Daniel had a 99-yard kickoff return and an 81-yard punt return nullified by penalties before Craig Jones broke a 90-yard TD run as the first half ended.
The Devils broke the game open with 3 touchdowns in the third, and the clock ran in the fourth. The Devils totaled 551 offensive yards, including 446 on the ground. Pace attempted 39 passes, but the Devils intercepted 4.
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| 6 | 41 | Fri, Nov 10, 2023 | Wilkinson County | W | 41-0 | T | ['more'] |
| 7 | 40 | Fri, Nov 22, 1985 | Louisville | W | 40-0 | T | ['more'] |
| L had allowed 40 pts all year |
| 8 | 38 | Thu, Nov 22, 1962 | Monticello | W | 38-0 | H | ['more'] |
| 8 | 38 | Fri, Nov 20, 1992 | Louisville | W | 38-0 | H | ['more'] |
| 67th consecutive region victory |
| 8 | 38 | Fri, Nov 24, 2000 | Wesleyan | W | 45-7 | H | ['more'] |