Largest Losing Margin, Home Games
| Rank | Difference | Date | Opponent | | Score | Location | Click for details |
| 1 | 57 | Fri, Aug 17, 2018 | Abbeville, SC | L | 0-57 | H | ['more'] |
| Abbeville 3-time defending SC AA state champs. Panthers scored on their first offensive play and never looked back. 36-0 at half. Most points ever allowed and biggest loss in Devil history. |
| 2 | 47 | Thu, Nov 26, 1953 | Washington-Wilkes | L | 0-47 | H | ['more'] |
| 2 | 47 | Fri, Nov 4, 1966 | Warren County | L | 0-47 | H | ['more'] |
| 3000+ spectators; L 2C runnerup; 2nd worst loss in L history |
| 4 | 45 | Fri, Nov 3, 1972 | Aquinas | L | 0-45 | H | ['more'] |
| 5 | 38 | Fri, Nov 12, 1954 | Wrens | L | 0-38 | H | ['more'] |
| 5 | 38 | Fri, Sep 21, 1951 | Louisville | L | 0-38 | H | ['more'] |
| 7 | 34 | Fri, Oct 9, 1936 | Athens | L | 0-34 | H | ['more'] |
| 7 | 34 | Thu, Nov 26, 1942 | Washington-Wilkes | L | 0-34 | H | ['more'] |
| Thanksgiving afternoon; Chronicle reports score as 34-0 |
| 7 | 34 | Thu, Nov 22, 1951 | Washington-Wilkes | L | 0-34 | H | ['more'] |
| 10 | 29 | Fri, Nov 10, 1972 | Waynesboro | L | 13-42 | H | ['more'] |
| 10 | 29 | Fri, Oct 12, 2018 | Greene County | L | 7-36 | H | ['more'] |
| The following week, Greene County beat Aquinas to win Subdivision B. |
In 11 games:
Winning Percentage: 0.000
Total scored: 20
Total allowed: 452
Average game: 1.82-41.09
Shutouts by Red Devils: 0
Shutouts by opponents: 9